skincareRX HYDRAFIX HA Clinical Complex

Description

1% HA (Hyaluronic Acid)
High Molecular Weight HA is ideal for professional use during Collagen Induction Therapy (CIT) or electroporation.

Why Use High Molecular Weight Hyaluronic Acid (HMWHA) Instead of Low Molecular Weight Hyaluronic Acid (LMWHA) During Professional Treatments, Especially Post-Needling?

Following tissue injury, monocytes can enter the tissue and differentiate into fibroblast-like cells called fibrocytes. However, the regulation of this differentiation is not fully understood.

The extracellular matrix contains high molecular weight hyaluronic acid (HMWHA; ∼2×10^6 Da). During injury, HMWHA breaks down into low molecular weight hyaluronic acid (LMWHA; ∼0.8–8×10^5 Da).

• HMWHA: Promotes the differentiation of human monocytes into fibrocytes and supports regenerative healing in adult wounds. Monocytes internalize HMWHA and LMWHA equally well.

• LMWHA: Inhibits fibrocyte differentiation and increases the expression of macrophage inflammatory protein-1α and monocyte chemotactic protein-1, suggesting its role in inducing the inflammatory cascade.

Suitable For: All Skin Types